Rheumatology

Lauren M. Pachman, MD

• Professor of Pediatrics, Northwestern University's Feinberg School of Medicine
• Director, Disease Pathogenesis Core, Children's Memorial Research Center
• Co-Director, Biomedical Research Component, Northwestern University Multipurpose Arthritis and Musculoskeletal Diseases Center
• Attending Physician, Rheumatology, Children's Memorial Hospital

Contact Information:

• Phone: 773.880.4303
• Fax: 773.880.4179
• E-mail: pachman@northwestern.edu

Certification

• American Board of Pediatrics, 1966, 1992, 1999
• American Board of Allergy & Clinical Immunology, 1974
• American Board of Pediatrics - Sub-Board Pediatric Rheumatology, 1992, 1999

Education

• BA, Wellesley College
• MD, University of Chicago Medical School

Residency/Fellowship

• Rotating Internship: Philadelphia General Hospital
• Pediatric Residency: Columbia-Presbyterian's Babies Hospital
• NIH post-doctoral fellowship in Immunology: Rockefeller University undefined
• Honors: NIH post-doctoral fellow; University of Chicago Medical Alumnae: Distinguished Service Award; The Best Doctors In America, 1996 —

Honors

• NIH postdoctoral fellow, 1964–1966
• University of Chicago Medical Alumnae Distinguished Service Award, 1989
• Listed in "America Best Doctors," American Health, 1996, 1998, 2000, 2002
• Erwin Neter Memorial Lecture Award: American Med Lab Immunologists, 1996
• University of Chicago Alumnae, Professional Achievement Award, 2001
• Master of Rheumatology, American College of Rheumatology, 2002
• Am Bd Pediatrics, Ped Rheumatol: Award of Distinction, 2003

Professional Organizations

• American Association of Immunologists
• Society of Pediatric Research
• American Pediatric Society
• American College of Rheumatology
• American Association for the Advancement of Science

Offices and Boards

• Midwest Society for Pediatric Research: Past President
• Chicago Rheumatism Society: Past President
• Pediatric Rheumatology Subsection, American Rheumatism Association: Past President
• National Arthritis Foundation:
  • Blue Ribbon Research Panel (1996)
  • Committee on Education and Patient Services (1994-1996)
• Chicago Association of Immunologists: President 1997-1999
• Clinical Immunology Society: Education Committee—current; Laboratory Council: current
• Board of Directors, Greater Illinois Chapter Arthritis Foundation, 1998-2004

Interests

Dr. Pachman's clinical and research interests center on the regulation of the immune response, both in children with vascular involvement and rheumatic disease, as well as those with primary immunodeficiency disease. Her specific focus is the study of factors affecting the onset and course of the most common pediatric inflammatory myopathy, juvenile dermatomyositis. This focus is implemented by both a national NIH funded study of the epidemiology of JDM (JDM - New Onset Juvenile Dermatomyositis Research Registry) and a NIAMS sponsored laboratory based investigation of genetic and immunological factors that may be associated with a short vs. a long disease course. The course of the disease is altered by therapy; prednisone and other steroids are the primary drugs now used to treat pediatric vascular inflammation. Another study reviews data provided by children admitted to the Clinical Research Center (no patient charges for study) concerning the way that vascular inflammation alters the absorption and metabolism of prednisone when the drug is given by mouth as compared to intravenous administration. In addition, other new biological agents are under investigation for their effect on JDM and other pediatric rheumatic disease. Further information concerning JDM can be obtained from the JDM web pages.

Most Recent Publications

(Selected from 122)

• Yel L, Minegishi Y, Coustan- Smith E, Buckley RH, Trubel H, Pachman LM, Kitchingman GR, Campana D, Rohrer J, Conley ME. Mutations in the Mu Heavy Chain Gene in Patients with Agammaglobulinemia. N Eng J Med, 335:1486-1493, 1996.
• Eisenstein DM, O'Gorman MRG, Pachman LM. Correlations between change in disease activity and changes in peripheral blood lymphocyte subsets in patients with juvenile dermatomyositis. J Rheum, 24:180-1832 1997.
• Eisenstein DM, Paller A, Pachman LM. Juvenile Dermatomyositis presenting with rash alone. Pediatrics, 100:391-392, 1997.
• Pachman LM, Hayford J, Hochberg MC, Pallansch MA, Daugherty, CD, Athreya BH, Bowyer SL, Fink C, Gewanter HL, Jerath R, Lang BA, Szer IS, Sinacore J, and Dyer A. New onset juvenile dermatomyositis: Comparisons with a healthy cohort and children with juvenile rheumatoid arthritis. Arthritis Rheum, 40, 1526-33, 1997.
• Mayes MD, Giannini EH, Pachman LM, Buyon JP, and Fleckman P. Connective Tissue Diseases Registries. Arthritis Rheum, 40:1556-9, 1997.
• O'Gorman, MRG, Zaas D, Paniagua M, Corrochano V, Scholl PR and Pachman LM. Development of a rapid whole blood flow cytometry procedure for the diagnosis of x-linked hyper-Igm syndrome patients and carriers. Clin Immunol Immunopathol 85:172- 181, 1997.
• Reed AM, Pachman LM, Hayford J, and Ober C. Immunogenetic studies in families of children with juvenile dermatomyositis (JDMS). J Rheumatol, 25:1000-1002, 1998.
• Miller ML, Algayed I, Yogev R, Chou P, Scholl PR, and Pachman LM. Atypical Pneumocystis carinii pneumonia in a child with Hyper-IgM syndrome. Pediat Pathol & Lab Med, 18:71-78, 1998.
• Klein-Gitelman, MS, Pachman LM. Intravenous pulse corticosteriods (CS): adverse reactions are more variable than expected in children. J Rheum, 25:1995-2002, 1998.
• Reed AM, Pachman LM, Hayford J, and Ober C. Immunogenetic studies in families of children with juvenile dermatomyositis (JDMS). J Rheumatol, 25: 1000-1002, 1998.
• Pachman LM, Hayford JR, Chung A, Daugherty CA, Pallansch MA, Fink CW, Gewanter HL, Jerath R, Lang bA, Sinacore J, Szer IS, Dyer AR and Hochberg MC. Juvenile dermatomyositis at diagnosis: clinical characteristics of 79 children. Arthritis Rheum 25:1198-204, 1998.
• Scholl PR, O'Gorman MRG, Pachman LM, Haut P, and Kletzel M. Correction of neutropenia and hypogammaglobulinemia in X-linked hyper-IGM syndrome by allogeneic bone marrow transplantation. Bone Marrow Transplantation, 22:1215-18, 1998.
• Eisenstein DM, Poznanski AK, and Pachman LM. Torg Syndrome. Am J Med Genet, 80:207-212, 1998.
• Abramson LS, Pachman LM, Abertini RJ and Finette BA. Association between Somatic HPRT mutant frequency, peripheral blood t-lymphocyte clonality and serologic parameters of disease activity in children with juvenile onset dermatomyositis. Clin Immunol and Immuno Pathol, 91:61-69, 1999. undefined
• Zachary CY, Pachman LM, Klein-Gitelman, M. Adverse Reactions to High Dose Intravenous Corticosteroids in five children with rheumatic diseases. Ann Allergy, Asthma & Immunol, in press, 1999. —
• O'Gorman MRG, Bianchi L, Zaas D, Corrochano V, and Pachman LM. Decreased CD54 (ICAM-1) Positive Lymphocytes in the peripheral blood of untreated active juvenile dermatomyositis (JDM) patients. Clin Diag Immunol, 7:693-697, 2000.
• Pachman LM, Liotta-Davis M, Hong D, Kinsella TR, Mendez E, Kinder J, and Chen EH. TNFa-308A allele in juvenile dermatomyositis-association with increased TNFa production, disease duration, and pathological calcifications. Arthritis Rheum, 43:2368-2377, 2000.
• Fedczyna TO, Lutz J, Pachman LM. Expression of TNFa by muscle fibers in biopsies from children with untreated juvenile dermatomyositis: association with the TNFa-308A allele. Clin Immunol 100:236-239, 2001.
• Tezak Z, Hoffman EP, Lutz JL, Fedczyna TO, Stephen D, Bremer EG, Krasnoselska-Riz I, Kumar A, and Pachman LM. Gene expression profiling in DQA1*0501+ children with untreated dermatomyositis: A novel model of pathogenesis. J Immunol. 168:4154-4163, 2002.
• Lutz M, Fedczyna T, Huwiler KG, Lechman TS, Crawford S, and Pachman LM. Increased plasma thrombospondin-1 (TSP-1) levels are associated with the TNFa-308A allele in children with juvenile dermatomyositis (JDM). Clin Immunol, 103:250-263, 2002.
• Massa M, Costouros N, Mazzoli F, DeBenedetti F, Bonnin D, Samodal R, Mendivil A, La Cava A, De Kleer I, Ravelli A, Liotta M, Pachman LM, Martini A, and Albani S. Self-epitopes shared between human skeletal myosin and Streptococcus pyogenes M5 protein are targets of immune responses in active juvenile dermatomyositis. Arthritis Rheum, 46: 3015-3025, 2002.
• Bode RK, Klein-Gitelman MS, Miller ML, Lechman TS and Pachman LM. Disease activity score for children with Juvenile Dermatomyositis (JDM): Reliability and validity evidence. Arthritis Care Res, 49: 7-15, 2003.
• Mendez E, Lipton R, Dyer A, Ramsey-Goldman R, Roettcher P, Bowyer S, and Pachman LM. U.S. Incidence of JDM 1995-98: Results from the NIAMS Registry. Arthritis Care Res, 49: 300-305, 2003.

Recent Chapters/Invited Publications

• Pachman LM & Poznanski AK : Juvenile (Rheumatoid) Arthritis. In: Arthritis and Related Conditions. (ed.) D. McCarthy and W. Koopman. Lea and Febiger, Malvern, PA., pp. 1155-1177, 1996.
• Pachman LM : Polymyositis and dermatomyositis in children. In The Oxford Textbook of Rheumatology. (ed.) Maddison PJ, Isenberg DA, Woo P, Glass DN, Oxford University Press, Oxford; pp.1287-1300, 1998.
• Pachman, LM. Juvenile Dermatomyositis: Epidemiology and Diagnostic Laboratory Data. Clinical Immunology Newsletter, 18, 105-112, 1998.
• Pachman LM. Myositis: In Adolescent Rheumatology ed. Maddison PJ, Isenberg DA, Woo P, Glass DN, Oxford University Press, Oxford; 127-146, 1999.
• Pachman LM & Miller FW. Idiopathic inflammatory myopathies: Dermatomyositis, Polymyositis, and Related Disorders, In: Samter's Immunologic Diseases 6th Edition. (Ed) KF Austen, MM Frank, JP Atkinson, H Cantor, Lippincott, Williams & Wilkins. Philadelphia, PA; pp. 94-105, 2001.
• Hoffman EP, Rao D, Pachman LM. Clarifying the boundaries between the inflammatory and dystrophic myopathies: insights from molecular diagnostics and microarrays. In: Rheumatic Disease Clinics of North America; Idiopathic Inflammatory Myopathies, (Ed) F.W. Miller; W.B. Saunders, Philadelphia, PA 28 (4):743-757, 2002.
• Pachman, LM. Juvenile Dermatomyositis: Immunogenetics, Pathophysiology and Disease Expression. In: Rheum Dis Clin North Am, Pediatric Issue, (Ed) M.L. Miller, W.B. Saunders, Philadelphia, PA; pp. 579-602, 2002.
• Pachman, LM. Juvenile dermatomyositis and other inflammatory myopathies in children. In: Neuromuscular disorders of infancy and childhood: a clinician's approach, (Ed) H.R. Jones, Jr., De Vivo DC, Darras BT, Woburn MA: Butterworth-Heinemann, Philadelphia, PA; pp 901-937, 2003.
• Miller, ML, and Pachman LM. Vasculitis Syndromes, In: Nelson Textbook of Pediatrics, 17th edition (Ed) RE Behrman, RM Kliegman and HB Jenson, WB Saunders, Philadelphia, PA; pp 826-831, 2003.
• Pachman LM. Juvenile Dermatomyositis, In: Nelson Textbook of Pediatrics, 17th edition (Ed) RE Behrman, RM Kliegman and HB Jenson, WB Saunders, Philadelphia, PA; pp 813-816, 2003.
• Klein-Gitelman MS, Miller ML and Pachman LM. Connective tissue disease in children. In: Rheumatology, third edition (Ed) Hockberg, Silman, Smoden, Weinblatt, Weisman, Harcourt Health Sciences, London; pp 1017-1025, 2003.